Human GRB2-associated-binding protein 1 (GAB1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GAB1
proveedor
Abbexareference
abx524634Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human GRB2-associated-binding protein 1 (GAB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human GRB2-associated-binding protein 1 (GAB1) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.
Características del producto
category
ELISA Kits
immunogen target
GRB2-associated-binding protein 1 (GAB1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
GRB2-associated binder 1,DFNB46
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GAB1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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