Human Glycophorin A (GYPA) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Glycophorin A (GYPA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx066879
tested applications
WB, SDS-PAGE
Description
Recombinant Glycophorin A (GYPA) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glycophorin A (GYPA) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 11.9 kDa Observed MW (SDS-PAGE): 15 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu20-Glu91 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_002090.4 |
| Alias | MNS blood group,MN,GPA,MNS,GPSAT,PAS-2,CD235a,MN sialoglycoprotein,Sialoglycoprotein alpha |
| Background | Protein GYPA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Glycophorin A (GYPA) is a major sialoglycoprotein found on the membrane of human red blood cells (RBCs) and plays a crucial role in the structure and function of the erythrocyte membrane. As a prominent surface protein, it is highly glycosylated and carries sialic acid residues, which contribute to the overall negative charge on the RBC surface, helping to prevent cell aggregation and maintain blood flow. GYPA is most recognized for its involvement in the MNS blood group system, which includes the MN and Ss antigens; variations in the GYPA gene form the molecular basis for these antigenic determinants. This protein is highly relevant in transfusion medicine due to its immunogenic potential and role in blood group antigenicity. In addition to its structural role, GYPA interacts with various pathogens, particularly Plasmodium falciparum, the causative agent of malaria. This interaction is significant for the pathogen’s adhesion to RBCs during infection. GYPA also functions as a receptor for viruses like influenza, playing a broader role in infectious disease dynamics.
