Human Glutamate Receptor, Metabotropic 3 (GRM3) Protein
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Description
Glutamate Receptor, Metabotropic 3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glutamate Receptor, Metabotropic 3 (GRM3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 58.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp568-Phe819 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | GRM3,GLUR3,mGlu, GPRC1C,MGLUR3,mGluR3,glutamate receptor |
| Background | Protein GRM3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
GRM3, also known as mGluR3, is a Group II metabotropic glutamate receptor that couples to Gi/o proteins, leading to the inhibition of adenylate cyclase and reduced cAMP production. GRM3 is expressed in glial cells and neurons, where it modulates synaptic transmission, glutamate release, and neuroinflammation. GRM3 plays an important role in maintaining synaptic plasticity and protecting against excitotoxicity by regulating extracellular glutamate levels. Dysregulation of GRM3 has been linked to psychiatric disorders, including schizophrenia, where genetic variations in the GRM3 gene are associated with cognitive deficits and impaired glutamatergic signaling. GRM3 is also involved in neuroprotection, reducing oxidative stress and inflammation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. GRM3 agonists are being explored as therapeutic agents for schizophrenia, neuroinflammation, and cognitive impairment, as they stabilize glutamate levels and improve neuronal function. Its role in glutamate homeostasis highlights its therapeutic potential in CNS disorders.
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Glutamate Receptor, Metabotropic 3 (GRM3) Antibody
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