Human Glucocorticoid Receptor (NR3C1) ELISA Kit

Este producto es parte de NR3C - nuclear receptor subfamily 3 group C member
Human Glucocorticoid Receptor (NR3C1) ELISA Kit
689€ (96 tests)

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Name
Human Glucocorticoid Receptor (NR3C1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx152554
Tested Applications
ELISA

Description

Human Glucocorticoid Receptor (NR3C1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Glucocorticoid Receptor (NR3C1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Glucocorticoid Receptor (NR3C1)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Glucocorticoid Receptor (NR3C1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.07 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
GR,GCR,GRL,GCCR,GCRST,Glucocorticoid receptor
Background
Elisa Kits for: NR3C1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Nuclear receptor subfamily 3 group C member 1 (NR3C1), also known as the glucocorticoid receptor (GR), is a nuclear receptor that mediates the effects of glucocorticoids, hormones involved in stress response, metabolism, and immune function NR3C1 is activated by glucocorticoids, such as cortisol, and regulates the expression of genes involved in inflammation, immune suppression, and metabolism It is expressed in a variety of tissues, including the liver, immune cells, and brain, where it influences processes such as glucose metabolism, fat storage, and the immune response NR3C1 plays a key role in the body’s response to stress by regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the production of cortisol and other stress hormones Dysregulation of NR3C1 signaling has been linked to various diseases, including metabolic syndrome, depression, autoimmune disorders, and cancer, where improper glucocorticoid signaling can contribute to inflammation, altered metabolism, and immune dysfunction GR is also a target for corticosteroid drugs used to treat conditions like asthma, arthritis, and autoimmune diseases

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