Human Glucagon receptor (GCGR) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Glucagon receptor (GCGR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx525444
tested applications
ELISA
Description
Human Glucagon receptor (GCGR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Glucagon receptor (GCGR) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Glucagon receptor (GCGR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P47871 |
| Gene ID | 2642 |
| OMIM | 138033 |
| Alias | GCGR,GGR,GL-R,GR,MVAH |
| Background | Elisa kits for GCGR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GCGR is a G protein-coupled receptor activated by glucagon, a hormone secreted by pancreatic α-cells during fasting to maintain blood glucose levels. GCGR is predominantly expressed in the liver, where its activation stimulates glycogenolysis and gluconeogenesis, increasing glucose production to prevent hypoglycemia. GCGR signaling activates the cAMP/PKA pathway, leading to the mobilization of glucose stores and fatty acid oxidation. Beyond its role in glucose homeostasis, GCGR is involved in lipid metabolism, ketogenesis, and energy balance. Dysregulation of GCGR contributes to hyperglycemia in conditions such as type 2 diabetes, where elevated glucagon levels exacerbate glucose production. GCGR is also expressed in extrahepatic tissues like the heart and kidney, where it plays roles in cardiovascular function and energy expenditure. GCGR antagonists are being developed as therapeutic strategies to reduce hepatic glucose output and improve glycemic control in diabetes. Additionally, GCGR agonism has been explored for weight loss and fatty liver disease due to its effects on energy balance. GCGR is a central regulator of glucose and energy metabolism, making it a key target for metabolic disease treatment.
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