Human Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1 (GABARAPL1) Protein
338€ (10 µg)
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Name
Human Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1 (GABARAPL1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692959
Tested Applications
SDS-PAGE
Description
Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1 (GABARAPL1) protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1 (GABARAPL1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Lys117 Tag: N-terminal 6 His tag |
| Origin | Human |
| Observed MW | 16.2 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM PBS, 150 mM NaCl, pH 7.2. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9H0R8 |
| Alias | APG8-LIKE,APG8L,ATG8,ATG8B,ATG8L,GEC1 |
| Background | Protein GABARAPL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
GABARAPL1 is a member of the GABARAP (GABA-A receptor-associated protein) family, which plays a key role in intracellular trafficking, autophagy, and receptor regulation. It facilitates the transport and membrane localization of GABA-A receptors, contributing to inhibitory neurotransmission in the central nervous system. Beyond its role in neurotransmitter signaling, GABARAPL1 is a critical component of the autophagy machinery, interacting with ATG proteins to regulate autophagosome formation and cargo sequestration. It is involved in cellular homeostasis, protein degradation, and stress responses. Dysregulation of GABARAPL1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where impaired autophagy disrupts protein clearance and neuronal survival. GABARAPL1 is also implicated in cancer, where altered expression influences tumor progression, survival, and chemoresistance through autophagy modulation. Its dual role in receptor trafficking and autophagy highlights GABARAPL1 as a critical regulator of cellular and neuronal function, making it a potential therapeutic target in neurodegeneration and cancer.
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