Human GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Protein
338€ (10 µg)
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935106861
info@markelab.com
name
Human GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692959
tested applications
SDS-PAGE
Description
Human GABA Receptor-Associated Protein is a recombinant protein from Human produced in E. coli. Recombinant Human gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1 is produced by our E.coli expression system and the target gene encoding Met1-Lys117 is expressed with a 6His tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | GABA Receptor-Associated |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 16.2 kDa Sequence Fragment: Met1-Lys117 Tag: N-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mM NaCl, pH 7.2. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q9H0R8 |
| Alias | APG8-LIKE,APG8L,ATG8,ATG8B,ATG8L,GEC1 |
| Background | Protein GABARAPL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
GABARAPL1 is a member of the GABARAP (GABA-A receptor-associated protein) family, which plays a key role in intracellular trafficking, autophagy, and receptor regulation. It facilitates the transport and membrane localization of GABA-A receptors, contributing to inhibitory neurotransmission in the central nervous system. Beyond its role in neurotransmitter signaling, GABARAPL1 is a critical component of the autophagy machinery, interacting with ATG proteins to regulate autophagosome formation and cargo sequestration. It is involved in cellular homeostasis, protein degradation, and stress responses. Dysregulation of GABARAPL1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where impaired autophagy disrupts protein clearance and neuronal survival. GABARAPL1 is also implicated in cancer, where altered expression influences tumor progression, survival, and chemoresistance through autophagy modulation. Its dual role in receptor trafficking and autophagy highlights GABARAPL1 as a critical regulator of cellular and neuronal function, making it a potential therapeutic target in neurodegeneration and cancer.
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