Human Frizzled Homolog 6 (FZD6) CLIA Kit
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Description
Human Frizzled Homolog 6 (FZD6) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Frizzled Homolog 6 (FZD6) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.119 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | FZD6,FZ6,FZ-6,HFZ6,NDNC1,NDNC10,frizzled family receptor 6 |
| Background | CLIA Kits FZD6 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
FZD6 is a non-canonical Wnt receptor primarily involved in planar cell polarity (PCP) signaling, which regulates cell orientation and migration. It is expressed in epithelial tissues, hair follicles, and the nervous system, where it controls processes like cell polarity, tissue morphogenesis, and embryonic development. FZD6 is essential for hair follicle orientation and skin development, as mutations in FZD6 are associated with conditions like nail dysplasia and abnormal hair patterns. In cancer, FZD6 is upregulated in gastric, breast, and ovarian cancers, where it promotes epithelial-mesenchymal transition (EMT), cell migration, and metastasis through non-canonical signaling pathways. FZD6 also regulates actin cytoskeleton dynamics, contributing to cell motility and invasion. In the nervous system, FZD6 influences neuronal development and axon guidance, highlighting its role in neurodevelopmental processes. Dysregulation of FZD6 signaling leads to developmental defects and cancer progression. Its function in PCP signaling and cytoskeletal regulation positions FZD6 as a key target for therapies aimed at modulating cell polarity, tissue architecture, and cancer metastasis.
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