Human Free Fatty Acid Receptor 4 (FFAR4) Protein
1872€ (1 mg)
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935106861
info@markelab.com
name
Human Free Fatty Acid Receptor 4 (FFAR4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653467
tested applications
WB, SDS-PAGE
Description
Human Free Fatty Acid Receptor 4 (FFAR4) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Free Fatty Acid Receptor 4 (FFAR4) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | FFAR4,PGR4,GPR120,GPR129,G-protein-coupled receptor GT01,GT01,G protein-coupled receptor 120,G protein-coupled receptor 129,omega-3 fatty acid receptor 1,O3FAR1,G-protein coupled receptor GT01,OB10Q,BMIQ10 |
| Background | Protein FFAR4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FFAR4, also known as GPR120, is a G protein-coupled receptor activated by long-chain free fatty acids, including omega-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). FFAR4 is expressed in adipocytes, macrophages, and the gastrointestinal tract, where it regulates metabolism, inflammation, and insulin sensitivity. In adipose tissue, FFAR4 activation enhances insulin sensitivity and glucose uptake, while in macrophages, it suppresses pro-inflammatory signaling pathways, such as NF-κB, reducing chronic inflammation. FFAR4 also promotes the release of gut hormones like GLP-1, contributing to satiety and glucose homeostasis. Dysregulation of FFAR4 signaling is associated with obesity, insulin resistance, and inflammatory diseases, highlighting its role in metabolic and immune regulation. In cancer, FFAR4 activation has shown potential anti-tumor effects by modulating inflammation and cellular metabolism. FFAR4 is being explored as a therapeutic target for metabolic disorders, obesity, and inflammatory diseases due to its ability to mediate the beneficial effects of omega-3 fatty acids.
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