Human Folliculin (FLCN) CLIA Kit
845€ (96 tests)
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name
Human Folliculin (FLCN) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495616
tested applications
CLIA
Description
Human Folliculin Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Folliculin (FLCN) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.112 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | BHD,FLCL,DENND8B,Birt-Hogg-Dube syndrome protein,BHD skin lesion fibrofolliculoma protein |
| Background | CLIA Kits FLCN |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Folliculin (FCLN) is a tumor suppressor protein encoded by the FLCN gene and plays a key role in cellular energy sensing, metabolic regulation, and mTOR signaling pathways. It is widely implicated in Birt-Hogg-Dubé syndrome (BHD), a rare autosomal dominant disorder associated with renal cell carcinoma, lung cysts, and fibrofolliculomas. FCLN functions as a GTPase-activating protein (GAP) for RagC and RagD GTPases, facilitating the activation of the mTORC1 complex on lysosomal membranes in response to nutrient availability. Dysregulation of FCLN can lead to abnormal mTORC1 signaling, promoting unchecked cellular proliferation and metabolic imbalances. Folliculin is expressed in a variety of tissues, with high levels in the kidney, lung, and skin, correlating with the phenotypic manifestations of BHD. Structural studies indicate that FCLN forms a complex with folliculin-interacting proteins (FNIP1 and FNIP2), enhancing its role in AMPK regulation and energy homeostasis. Emerging research suggests that FCLN also influences autophagy and lysosomal biogenesis, positioning it as a critical regulator of cellular stress responses. Loss of function or mutations in FCLN disrupt cellular homeostasis, making cells more susceptible to oncogenic transformation. FCLN's interactions with FNIPs and its role in integrating metabolic and nutrient signals highlight its significance in maintaining cellular and tissue-level equilibrium.
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