Family main features
Folliculin (FLCN) is a tumor suppressor protein encoded by the FLCN gene located on chromosome 17p11.2. This protein is implicated in Birt-Hogg-Dubé (BHD) syndrome, a hereditary condition characterized by the development of skin fibrofolliculomas, pulmonary cysts, and an increased risk of renal cancer. FLCN functions in various cellular processes, including regulation of the mTOR (mechanistic target of rapamycin) signaling pathway, which is crucial for cell growth, proliferation, and survival. The gene was first identified due to its association with BHD syndrome, and subsequent research has expanded our understanding of its role in cellular homeostasis and disease.
Folliculin is a protein composed of 579 amino acids with a molecular weight of approximately 64 kDa. The structure of FLCN includes multiple functional domains:
FLCN does not have well-defined subtypes but interacts with various binding partners forming complexes:
Folliculin plays several critical roles in cellular physiology:
Mutations in the FLCN gene are linked to Birt-Hogg-Dubé syndrome, which predisposes individuals to:
Folliculin (FLCN) is a crucial tumor suppressor protein involved in multiple cellular processes, including mTOR signaling, energy homeostasis, and autophagy. The protein's structure features several domains essential for its interactions with other proteins and its regulatory functions. FLCN's role in disease is most prominently observed in Birt-Hogg-Dubé syndrome, but its broader implications in cancer and metabolism are significant. Understanding FLCN's mechanisms offers insights into potential therapeutic targets for various conditions linked to its dysregulation.
folliculin (FCLN)
BHD,FLCL,DENND8B,Birt-Hogg-Dube syndrome protein,BHD skin lesion fibrofolliculoma protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con FLCN - foliculin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | FLCN | abx495616 | Human Folliculin (FLCN) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.112 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | FLCN | abx151577 | Human Folliculin (FLCN) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | FLCN | abx389320 | Mouse Folliculin (FLCN) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q8QZS3 | RUO |
Abbexa | FLCN | abx391347 | Rat Folliculin (FLCN) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q76JQ2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | FLCN | FNab10758 | anti- FLCN antibody | human | polyclonal | Rabbit | folliculin | IgG | Unconjugated | ELISA, WB | 100µg | Q8NFG4 | RUO | |
FineTest | FLCN | FNab03157 | anti- FLCN antibody | human | polyclonal | Rabbit | folliculin | IgG | Unconjugated | ELISA, WB, IHC, IP | 100µg | Q8NFG4 | RUO | |
Abbexa | FLCN | abx004978 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | WB | 175 | 20 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx341876 | Folliculin (FLCN) Antibody (FITC) | Human | Polyclonal | Rabbit | Folliculin (FLCN) | FITC | 250 | 50 µl | Q8NFG4 | RUO | ||
Abbexa | FLCN | abx034049 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx240205 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, WB | 350 | 100 µg | Q8NFG4 | RUO | |
Abbexa | FLCN | abx376346 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | Q8NFG4 | RUO | |
Abbexa | FLCN | abx341874 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx341877 | Folliculin (FLCN) Antibody (Biotin) | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Biotin | ELISA | 250 | 50 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx341875 | Folliculin (FLCN) Antibody (HRP) | Human | Polyclonal | Rabbit | Folliculin (FLCN) | HRP | ELISA | 250 | 50 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx213763 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx214841 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx112567 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, IHC | 612.5 | 100 µl | Q8NFG4 | RUO | |
Abbexa | FLCN | abx233157 | Folliculin (FLCN) Antibody | Human | Polyclonal | Rabbit | Folliculin (FLCN) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | Q8NFG4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FLCN | abx653446 | Human Folliculin (FLCN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
FineTest | FLCN | P1339 | Recombinant Human FLCN | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q8NFG4 | RUO |
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