Human Follicle Stimulating Hormone Receptor (FSHR) Protein

Este producto es parte de FSHR - Follicle Stimulating Hormone Receptor
Human Follicle Stimulating Hormone Receptor (FSHR) Protein

Pida mas información

935106861

info@markelab.com

Precio

273€ (10 µg)

Protein FSHR

proveedor

Abbexa

reference

abx066683

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Follicle Stimulating Hormone Receptor (FSHR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Follicle Stimulating Hormone Receptor (FSHR)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 12.3 kDa Observed MW (SDS-PAGE): 14 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys18-Pro113 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

FSHR


dry ice

No


availability

Shipped within 5-7 working days.


alias

FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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