Human Follicle Stimulating Hormone Receptor (FSHR) Protein

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935106861
info@markelab.com
Precio
273€ (10 µg)
Protein FSHR
proveedor
Abbexareference
abx066683Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Follicle Stimulating Hormone Receptor (FSHR) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Follicle Stimulating Hormone Receptor (FSHR)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 12.3 kDa Observed MW (SDS-PAGE): 14 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys18-Pro113 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FSHR
dry ice
No
availability
Shipped within 5-7 working days.
alias
FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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