Follicle Stimulating Hormone Receptor (FSHR) Antibody
52€ (10 µg)
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Name
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015281
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against FSHR protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Follicle Stimulating Hormone Receptor (FSHR) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human FSHR. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23945 |
| Alias | FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1 |
| Background | Antibody anti-FSHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.
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