Human Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit

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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for FRS3
proveedor
Abbexareference
abx387421Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human FRS3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Fibroblast growth factor receptor substrate 3 (FRS3) is another adaptor protein involved in FGFR signaling pathways. Like FRS2, FRS3 becomes tyrosine-phosphorylated upon FGFR activation and serves as a scaffold for the assembly of signaling complexes. FRS3 interacts with various signaling proteins, including Grb2 and Sos, to activate the Ras/MAPK pathway, promoting cellular proliferation and differentiation. Although FRS3 shares functional similarities with FRS2, it is known for its distinct tissue distribution and specific engagement with particular FGFR isoforms. These unique interactions suggest that FRS3 may play specialized roles in certain biological contexts. FRS3's involvement in FGFR signaling also links it to developmental processes and pathological conditions such as cancer. Understanding FRS3's unique contributions to FGFR signaling can provide insights into its potential as a therapeutic target in diseases involving aberrant FGFR activity.
Características del producto
category
ELISA Kits
immunogen target
Fibroblast Growth Factor Receptor Substrate 3 (FRS3)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
FRS2-beta,FRS2B,FRS2beta,SNT-2,SNT2,FGFR substrate 3,FGFR-signaling adaptor SNT2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
FRS3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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