Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

Este producto es parte de FRS - Fibroblast growth factor receptor substrate
Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein FRS2

proveedor

Abbexa

reference

abx066619

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Fibroblast Growth Factor Receptor Substrate 2 (FRS2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 27.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp239-Asn449 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

FRS2


dry ice

No


availability

Shipped within 5-7 working days.


alias

FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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status

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clonality

polyclonal

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