Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein FRS2
proveedor
Abbexareference
abx066619Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Fibroblast Growth Factor Receptor Substrate 2 (FRS2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 27.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp239-Asn449 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FRS2
dry ice
No
availability
Shipped within 5-7 working days.
alias
FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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