Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

Este producto es parte de FRS - Fibroblast growth factor receptor substrate
Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit
715€ (96 tests)

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Name
Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx252483
Tested Applications
ELISA

Description

Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human FRS2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Fibroblast Growth Factor Receptor Substrate 2 (FRS2)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
15.6 pg/ml - 1000 pg/ml
Sensitivity
9.38 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q8WU20
Alias
FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT
Background
Elisa Kits for: FRS2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.

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