Human Fibroblast Growth Factor 23 (FGF23) Protein

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935106861
info@markelab.com
Precio
429€ (50 µg)
Protein FGF23
proveedor
Abbexareference
abx655637Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Fibroblast Growth Factor 23 (FGF23) Protein (Active) is an Active Recombinant Human protein.
Background
FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Fibroblast Growth Factor 23 (FGF23)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 12.9 kDa Observed MW: 14 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala24-Val126 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FGF23
dry ice
No
availability
Shipped within 5-7 working days.
alias
ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor
uniprot id
NCBI accession
NP_065689.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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