Human Fibroblast Growth Factor 23 (FGF23) CLIA Kit
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935106861
info@markelab.com
Precio
845€ (96 tests)
CLIA Kits FGF23
proveedor
Abbexareference
abx491973Tested Applications
CLIAreactivity
Humanstatus
RUOclonality
Descripción
Human Fibroblast Growth Factor 23 (FGF23) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Background
FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.
Características del producto
category
CLIA Kits
immunogen target
Fibroblast Growth Factor 23 (FGF23)
reactivity
Human
test range
1.37 pg/ml - 1000 pg/ml
sensitivity
< 0.56 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Chemiluminescent
sample type
Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
FGF23
dry ice
No
uniprot id
NCBI accession
NP_065689.1
note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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