Human Fibroblast Growth Factor 21 (FGF21) Protein

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935106861
info@markelab.com
Precio
2561€ (1 mg)
Protein FGF21
proveedor
Abbexareference
abx655635Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Fibroblast Growth Factor 21 (FGF21) Protein (Active) is an Active Recombinant Human protein.
Background
FGF21 is a metabolic hormone belonging to the fibroblast growth factor family, primarily produced in the liver under conditions of fasting, stress, and ketogenic diet consumption. It regulates glucose metabolism, lipid homeostasis, and energy expenditure by activating FGF receptors in conjunction with the co-receptor β-Klotho. FGF21 enhances insulin sensitivity, promotes lipolysis in adipose tissue, and stimulates ketogenesis in the liver, making it a critical regulator during energy deficits. It has also been linked to reducing body weight and mitigating non-alcoholic fatty liver disease (NAFLD). Therapeutically, FGF21 analogs are being explored for treating type 2 diabetes, obesity, and metabolic disorders. Dysregulation of FGF21 has been observed in insulin resistance and cardiovascular diseases.
Características del producto
category
Proteins and Peptides
origin
Human
immunogen target
Fibroblast Growth Factor 21 (FGF21)
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FGF21
dry ice
No
availability
Shipped within 1-2 months.
alias
FGF-21
uniprot id
NCBI accession
NP_061986.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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