Human Fibroblast Growth Factor 19 (FGF19) Protein
234€ (5 µg)
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935106861
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name
Human Fibroblast Growth Factor 19 (FGF19) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx262135
tested applications
SDS-PAGE
Description
Fibroblast Growth Factor 19 (FGF19) His Tag Protein is a recombinant cytokine.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor 19 (FGF19) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 23 kDa Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques, followed by filtration (0.4 µm). |
| Size 1 | 5 µg |
| Size 2 | 25 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in distilled water to a concentration of approximately 0.5 mg/ml. Allow the lyophilized pellet to dissolve completely before use. Sterile filtration is recommended prior to use in cell culture. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 20 mM NaCl, pH 7.5. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. Store below -18 °C for long-term storage. Upon reconstitution, store at 4 °C for up to 7 days and store below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95750 |
| Gene ID | 9965 |
| OMIM | 603891 |
| Alias | FGF-19 |
| Background | Protein FGF19 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FGF19 is a metabolic hormone primarily produced in the ileum of the small intestine in response to bile acid signaling where it regulates bile acid homeostasis by suppressing cholesterol 7α-hydroxylase (CYP7A1) expression in the liver FGF19 also promotes glucose metabolism, lipid homeostasis, and energy expenditure through signaling pathways involving its receptor FGFR4 and the co-receptor β-Klotho Dysregulation of FGF19 has been linked to non-alcoholic fatty liver disease (NAFLD), insulin resistance, and obesity Elevated FGF19 levels are also observed in liver cancers such as hepatocellular carcinoma (HCC) where its overactivation promotes tumor growth by driving cell proliferation and survival FGF19 analogs are being explored as therapies for metabolic disorders, including type 2 diabetes and dyslipidemia
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