Fibroblast Growth Factor 19 (FGF19) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Fibroblast Growth Factor 19 (FGF19) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx030119
Tested Applications
ELISA, WB
Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fibroblast Growth Factor 19 (FGF19) Immunogen: KLH-conjugated synthetic peptide between 175-202 amino acids from the C-terminal region of human FGF19. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 24 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95750 |
| Gene ID | 9965 |
| OMIM | 603891 |
| Alias | FGF-19 |
| Background | Antibody anti-FGF19 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FGF19 is a metabolic hormone primarily produced in the ileum of the small intestine in response to bile acid signaling where it regulates bile acid homeostasis by suppressing cholesterol 7α-hydroxylase (CYP7A1) expression in the liver FGF19 also promotes glucose metabolism, lipid homeostasis, and energy expenditure through signaling pathways involving its receptor FGFR4 and the co-receptor β-Klotho Dysregulation of FGF19 has been linked to non-alcoholic fatty liver disease (NAFLD), insulin resistance, and obesity Elevated FGF19 levels are also observed in liver cancers such as hepatocellular carcinoma (HCC) where its overactivation promotes tumor growth by driving cell proliferation and survival FGF19 analogs are being explored as therapies for metabolic disorders, including type 2 diabetes and dyslipidemia
Productos relacionados
Fibroblast Growth Factor 19 (FGF19) Antibody
Fibroblast Growth Factor 19 (FGF19) Antibody is a Rabbit Polyclonal Antibody against Fibroblast Growth Factor 19 (FGF19)…
Ver producto Fibroblast Growth Factor 19 (FGF19) Antibody
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess br…
Ver producto
Rat Fibroblast Growth Factor 19 (FGF19) Protein
Rat Fibroblast Growth Factor 19 (FGF19) is a recombinant Rat protein expressed in E. coli.…
Ver producto