Human Fibroblast Growth Factor 19 (FGF19) Protein
234€ (5 µg)
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Name
Human Fibroblast Growth Factor 19 (FGF19) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx260746
Tested Applications
SDS-PAGE
Description
Fibroblast Growth Factor 19 (FGF19) Protein is a recombinant cytokine.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor 19 (FGF19) |
| Host | E. coli |
| Assay Type | Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of balb/c 3T3 cells is 100-150 ng/ml. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 21.8 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE and RP-HPLC) |
| Purification | Purified by proprietary chromatographic techniques, followed by filtration (0.2 µm). |
| Size 1 | 5 µg |
| Size 2 | 25 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. Store below -18°C for long-term storage. Upon reconstitution, store at 4°C for up to 7 days and store below -18°C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95750 |
| Gene ID | 9965 |
| OMIM | 603891 |
| Alias | FGF-19 |
| Background | Protein FGF19 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 100 µg/ml. This stock solution can be further diluted if required. |
Background
FGF19 is a metabolic hormone primarily produced in the ileum of the small intestine in response to bile acid signaling where it regulates bile acid homeostasis by suppressing cholesterol 7α-hydroxylase (CYP7A1) expression in the liver FGF19 also promotes glucose metabolism, lipid homeostasis, and energy expenditure through signaling pathways involving its receptor FGFR4 and the co-receptor β-Klotho Dysregulation of FGF19 has been linked to non-alcoholic fatty liver disease (NAFLD), insulin resistance, and obesity Elevated FGF19 levels are also observed in liver cancers such as hepatocellular carcinoma (HCC) where its overactivation promotes tumor growth by driving cell proliferation and survival FGF19 analogs are being explored as therapies for metabolic disorders, including type 2 diabetes and dyslipidemia
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