Human Fibroblast Growth Factor 19 (FGF19) CLIA Kit
643.5€ (96 tests)
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name
Human Fibroblast Growth Factor 19 (FGF19) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195621
tested applications
CLIA
Description
Human Fibroblast Growth Factor 19 (FGF19) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Fibroblast Growth Factor 19 (FGF19).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Fibroblast Growth Factor 19 (FGF19) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 7.81 pg/ml - 500 pg/ml |
| Sensitivity | 4.69 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O95750 |
| Gene ID | 9965 |
| OMIM | 603891 |
| Alias | FGF-19 |
| Background | CLIA Kits FGF19 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
FGF19 is a metabolic hormone primarily produced in the ileum of the small intestine in response to bile acid signaling where it regulates bile acid homeostasis by suppressing cholesterol 7α-hydroxylase (CYP7A1) expression in the liver FGF19 also promotes glucose metabolism, lipid homeostasis, and energy expenditure through signaling pathways involving its receptor FGFR4 and the co-receptor β-Klotho Dysregulation of FGF19 has been linked to non-alcoholic fatty liver disease (NAFLD), insulin resistance, and obesity Elevated FGF19 levels are also observed in liver cancers such as hepatocellular carcinoma (HCC) where its overactivation promotes tumor growth by driving cell proliferation and survival FGF19 analogs are being explored as therapies for metabolic disorders, including type 2 diabetes and dyslipidemia
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