Human FGF2 Protein
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Description
Human FGF2 Protein is a recombinant protein from E. Coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | FGF basic, FGF2 |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 18 kDa |
| Expression | Recombinant |
| Purity | > 95% (HPLC and SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized Reconstitute with sterile 18MΩ-cm H2O. |
| Tested Applications | HPLC, SDS-PAGE |
| Buffer | 10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at -20°C or -80°C for long term. After reconstituting, it can be stored at 4°C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09038 |
| Gene ID | 2247 |
| OMIM | 134920 |
| Alias | FGF-2,Basic fibroblast growth factor,Bfgf,Heparin-binding growth factor 2 (HBGF-2),FGFB |
| Background | Protein FGF2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FGF2, also referred to as basic fibroblast growth factor (bFGF), is a growth factor involved in critical cellular processes, including angiogenesis, wound healing, and tissue repair It binds to FGF receptors (FGFRs) and activates pathways like Ras/MAPK and PI3K/AKT, which regulate cell proliferation, survival, and differentiation FGF2 is expressed in endothelial cells, fibroblasts, and smooth muscle cells, where it drives vascularization during tissue repair and development It promotes stem cell maintenance and supports neurogenesis by enhancing neuronal survival and regeneration Dysregulated FGF2 contributes to tumor growth, angiogenesis, and metastasis in cancers such as breast cancer and glioblastoma Targeting FGF2 signaling is a therapeutic strategy in cancer treatment, tissue regeneration, and ischemic conditions
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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
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