Human Fc Fragment Of IgA Receptor / CD89 (FCAR) Protein
221€ (10 µg)
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935106861
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name
Human Fc Fragment Of IgA Receptor / CD89 (FCAR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168062
tested applications
WB, SDS-PAGE
Description
Human Fc Fragment Of IgA Receptor Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Fc Fragment Of IgA Receptor / CD89 (FCAR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 55.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln22-Asn227 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24071 |
| Gene ID | 2204 |
| OMIM | 147045 |
| Alias | CD89,FcalphaR,FcalphaRI,CTB-61M7.2,Immunoglobulin alpha Fc receptor, IgA Fc receptor |
| Background | Protein FCAR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The Fc alpha receptor (FCAR), also known as CD89, is a receptor protein expressed on the surface of certain immune cells, primarily neutrophils, monocytes, macrophages, and some dendritic cells. This receptor binds specifically to the Fc region of immunoglobulin A (IgA), the most abundant antibody found in mucosal secretions and an essential player in immune responses in the gastrointestinal and respiratory tracts. The interaction between CD89 and IgA is critical for initiating immune responses such as phagocytosis, cytokine production, and antibody-dependent cellular cytotoxicity (ADCC). The FCAR gene encoding CD89 is located on chromosome 19q13, and it belongs to the immunoglobulin (Ig) superfamily. The biological significance of CD89 lies in its role as a primary mediator of IgA-dependent immune mechanisms, making it essential in mucosal immunity and in the clearance of pathogens from the body.
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