Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ENTPD1
proveedor
Abbexareference
abx166563Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
ENTPD1 Protein is a recombinant Human protein expressed in E. coli.
Background
ENTPD1, also known as CD39, is a critical ectoenzyme involved in the regulation of extracellular nucleotide levels. It belongs to the family of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) that hydrolyze extracellular nucleotides, such as ATP and ADP, into their respective monophosphate forms (AMP). This enzymatic activity is crucial for modulating purinergic signaling, which is involved in various physiological processes, including immune responses, thrombosis, vascular function, and tissue homeostasis. ENTPD1 is primarily expressed on immune cells like T regulatory cells (Tregs), dendritic cells, macrophages, and endothelial cells. Its ability to degrade ATP and ADP limits pro-inflammatory and pro-thrombotic signaling, promoting an anti-inflammatory and antithrombotic environment. This makes ENTPD1 a significant player in maintaining immune tolerance, regulating inflammation, and controlling thrombosis.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu241-Leu486 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ENTPD1
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD39,SPG64,ATP-DPH,ATPDase,NTPDase-1,ATP diphosphohydrolase,Ecto-ATP diphosphohydrolase 1,Ecto-apyrase,Lymphoid cell activation antigen ,Nucleoside triphosphate diphosphohydrolase 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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