Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Protein

Este producto es parte de ENTPD1 - ectonucleoside triphosphate diphosphohydrolase 1
Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Protein

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935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ENTPD1

proveedor

Abbexa

reference

abx166563

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

ENTPD1 Protein is a recombinant Human protein expressed in E. coli.


Background

ENTPD1, also known as CD39, is a critical ectoenzyme involved in the regulation of extracellular nucleotide levels. It belongs to the family of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) that hydrolyze extracellular nucleotides, such as ATP and ADP, into their respective monophosphate forms (AMP). This enzymatic activity is crucial for modulating purinergic signaling, which is involved in various physiological processes, including immune responses, thrombosis, vascular function, and tissue homeostasis. ENTPD1 is primarily expressed on immune cells like T regulatory cells (Tregs), dendritic cells, macrophages, and endothelial cells. Its ability to degrade ATP and ADP limits pro-inflammatory and pro-thrombotic signaling, promoting an anti-inflammatory and antithrombotic environment. This makes ENTPD1 a significant player in maintaining immune tolerance, regulating inflammation, and controlling thrombosis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 32.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu241-Leu486 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ENTPD1


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD39,SPG64,ATP-DPH,ATPDase,NTPDase-1,ATP diphosphohydrolase,Ecto-ATP diphosphohydrolase 1,Ecto-apyrase,Lymphoid cell activation antigen ,Nucleoside triphosphate diphosphohydrolase 1 


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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