Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Antibody
273€ (100 µl)
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Name
Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx104525
Tested Applications
IHC
Description
Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Immunogen: ENTPD1 (Thr98-Leu352) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD39,SPG64,ATP-DPH,ATPDase,NTPDase-1,ATP diphosphohydrolase,Ecto-ATP diphosphohydrolase 1,Ecto-apyrase,Lymphoid cell activation antigen ,Nucleoside triphosphate diphosphohydrolase 1 |
| Background | Antibody anti-ENTPD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ENTPD1, also known as CD39, is a critical ectoenzyme involved in the regulation of extracellular nucleotide levels. It belongs to the family of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) that hydrolyze extracellular nucleotides, such as ATP and ADP, into their respective monophosphate forms (AMP). This enzymatic activity is crucial for modulating purinergic signaling, which is involved in various physiological processes, including immune responses, thrombosis, vascular function, and tissue homeostasis. ENTPD1 is primarily expressed on immune cells like T regulatory cells (Tregs), dendritic cells, macrophages, and endothelial cells. Its ability to degrade ATP and ADP limits pro-inflammatory and pro-thrombotic signaling, promoting an anti-inflammatory and antithrombotic environment. This makes ENTPD1 a significant player in maintaining immune tolerance, regulating inflammation, and controlling thrombosis.
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