Human Dopamine Receptor D1 (DRD1) ELISA Kit

Product specifications

ELISA Kits

Dopamine Receptor D1 (DRD1)

Human

Colorimetric

Quantitative

Sandwich

0.312 ng/ml - 20 ng/ml

0.19 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P21728

DRD1,D1A,DADR,Gpcr15,dopamine D1 receptor,Dopamine-1A receptor,D1 receptor,Drd-1,Drd1a

Elisa kits for DRD1

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

DRD1 is a G protein-coupled receptor (GPCR) that belongs to the D1-like receptor family and is the most abundant dopamine receptor in the central nervous system (CNS). It is primarily expressed in brain regions such as the striatum, prefrontal cortex, and hippocampus, where it modulates motor control, cognition, and reward signaling. DRD1 couples to Gs proteins, leading to activation of adenylate cyclase, which increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A (PKA) pathways. DRD1 signaling enhances synaptic plasticity, learning, and memory formation and plays a key role in mediating motivation and reinforcement behaviors. Dysregulation of DRD1 activity has been implicated in neuropsychiatric disorders, including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and drug addiction, where abnormal dopaminergic transmission disrupts behavior and cognition. In Parkinson’s disease, reduced DRD1 signaling contributes to motor dysfunction due to dopamine depletion. DRD1 is also involved in cardiovascular regulation and renal function, influencing blood pressure and sodium balance. Pharmacological targeting of DRD1 with agonists or antagonists has therapeutic potential for neurological disorders, such as Parkinson’s and schizophrenia, as well as cardiovascular conditions.

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