Dopamine Receptor D1 (DRD1) Antibody

Este producto es parte de DRD - Dopamine Receptor D
Product Graph
949€ (100 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Dopamine Receptor D1 (DRD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx022553
tested applications
ELISA, WB, IF/ICC

Description

D1 Dopamine Receptor Antibody is a Rabbit polyclonal antibody for neuroscience against D1 Dopamine Receptor.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Dopamine Receptor D1 (DRD1)
Host
Rabbit
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Neat.
Size 1
100 µl
Form
Lyophilized
Tested Applications
ELISA, WB, IF/ICC
Buffer
Buffer contains no preservative.
Availability
Shipped within 10-20 working days.
Storage
Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
DRD1,D1A,DADR,Gpcr15,dopamine D1 receptor,Dopamine-1A receptor,D1 receptor,Drd-1,Drd1a
Background
Antibody anti-DRD1
Status
RUO

Descripción

DRD1 is a G protein-coupled receptor (GPCR) that belongs to the D1-like receptor family and is the most abundant dopamine receptor in the central nervous system (CNS). It is primarily expressed in brain regions such as the striatum, prefrontal cortex, and hippocampus, where it modulates motor control, cognition, and reward signaling. DRD1 couples to Gs proteins, leading to activation of adenylate cyclase, which increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A (PKA) pathways. DRD1 signaling enhances synaptic plasticity, learning, and memory formation and plays a key role in mediating motivation and reinforcement behaviors. Dysregulation of DRD1 activity has been implicated in neuropsychiatric disorders, including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and drug addiction, where abnormal dopaminergic transmission disrupts behavior and cognition. In Parkinson’s disease, reduced DRD1 signaling contributes to motor dysfunction due to dopamine depletion. DRD1 is also involved in cardiovascular regulation and renal function, influencing blood pressure and sodium balance. Pharmacological targeting of DRD1 with agonists or antagonists has therapeutic potential for neurological disorders, such as Parkinson’s and schizophrenia, as well as cardiovascular conditions.

Related Products

FNab02532

DRD1 antibody

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Ver Producto
P8786

Recombinant Human DRD1

Ver Producto
abx002124

Dopamine Receptor D1 (DRD1) Antibody

DRD1 Antibody is a Rabbit Polyclonal antibody against DRD1. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

Ver Producto