Human Docking Protein 4 (DOK4) ELISA Kit

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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DOK4
proveedor
Abbexareference
abx386970Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Docking Protein 4 (DOK4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOK4 concentrations in serum, plasma and other biological fluids.
Background
DOK4 is an adaptor protein belonging to the DOK family, involved in signal transduction downstream of receptor tyrosine kinases, such as RET and insulin receptors. It modulates pathways like MAPK/ERK and PI3K/Akt, influencing cellular proliferation, survival, and differentiation. DOK4 is expressed in tissues like skeletal muscle, adipose tissue, and the nervous system, where it regulates metabolic signaling and cellular responses. It acts as a negative regulator of signaling by binding to SH2 domains and inhibiting downstream activation. Dysregulation of DOK4 is associated with metabolic disorders, insulin resistance, and certain cancers, where it influences cell adhesion and motility.
Características del producto
category
ELISA Kits
immunogen target
Docking Protein 4 (DOK4)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
alias
Downstream of tyrosine kinase 4,Insulin receptor substrate 5,IRS-5,IRS5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DOK4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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