DOK4 Antibody is a Rabbit Polyclonal antibody against DOK4. The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Docking Protein 4 (DOK4)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
DOK4
No
Shipped within 5-10 working days.
Downstream of tyrosine kinase 4,Insulin receptor substrate 5,IRS-5,IRS5
NP_060580.2
This product is for research use only.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly o...
Precio a consultar
Ver másDOK4 Antibody is a Rabbit Polyclonal antibody against DOK4. The downstream of kinase family (Dok-1-7) are members of a c...
175€ (20 µl)
Ver másRabbit polyclonal antibody against DOK4 protein. Immunogen region is N-terminal.
43.75€ (10 µg)
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