Human DENN domain-containing protein 5B (DENND5B) ELISA Kit
715€ (96 tests)
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935106861
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name
Human DENN domain-containing protein 5B (DENND5B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510106
tested applications
ELISA
Description
Human DENN domain-containing protein 5B (DENND5B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENN domain-containing protein 5B (DENND5B) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DENN domain-containing protein 5B (DENND5B) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6ZUT9 |
| OMIM | 617279 |
| Alias | Rab6IP1-like protein |
| Background | Elisa kits for DENND5B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 5B (DENND5B) is a closely related paralog of DENND5A, acting as a guanine nucleotide exchange factor (GEF) for Rab GTPases and contributing to vesicular trafficking and lysosomal transport. DENND5B is particularly involved in activating Rab39, facilitating vesicle tethering, sorting, and fusion between late endosomes and lysosomes. It plays a key role in recycling membrane-bound receptors and transporters, ensuring efficient cellular signaling and nutrient uptake. DENND5B is also linked to autophagic processes, supporting the clearance of damaged cellular components and maintaining lysosomal integrity. Its expression is widespread, but it is highly active in tissues such as the brain and liver, which depend heavily on efficient vesicular transport systems. Dysregulation of DENND5B has been implicated in neurodegenerative diseases and metabolic syndromes, emphasizing its critical role in sustaining cellular proteostasis and responding to metabolic and environmental stress. Its close functional relationship with DENND5A highlights the importance of this subgroup in vesicular transport and cellular health.
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