Human DENN domain-containing protein 2D (DENND2D) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DENND2D
proveedor
Abbexareference
abx510098Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human DENN domain-containing protein 2D (DENND2D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENN domain-containing protein 2D (DENND2D) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
DENN domain containing 2D (DENND2D) is a guanine nucleotide exchange factor (GEF) within the DENN protein family, specifically targeting Rab GTPases, including Rab9. DENND2D plays a pivotal role in retrograde transport by activating Rab9 to facilitate vesicle movement between late endosomes and the trans-Golgi network. This transport is critical for recycling membrane proteins, maintaining lysosomal enzyme trafficking, and regulating receptor degradation. DENND2D is involved in cellular processes such as autophagy, endosomal sorting, and signaling pathways linked to cellular stress and growth. Its expression pattern suggests a broad functional relevance, particularly in tissues with active vesicular transport systems. Mutations or dysregulation of DENND2D have been associated with lysosomal storage disorders and other conditions resulting from impaired vesicle trafficking, underlining its importance in cellular health and homeostasis.
Características del producto
category
ELISA Kits
immunogen target
DENN domain-containing protein 2D (DENND2D)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
DENND2D
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DENND2D
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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