Human Dedicator of cytokinesis protein 5 (DOCK5) ELISA Kit

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator of cytokinesis protein 5 (DOCK5) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DOCK5

proveedor

Abbexa

reference

abx510795

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Dedicator of cytokinesis protein 5 (DOCK5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Dedicator of cytokinesis protein 5 (DOCK5) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

DOCK5, structurally similar to DOCK1, acts as a GEF for Rac1 and Cdc42, regulating actin polymerization during cell migration and bone resorption. It is essential for osteoclast function, promoting cytoskeletal organization and podosome formation. DOCK5 is expressed in skeletal and immune tissues, playing roles in osteoclast-mediated bone remodeling and macrophage migration. Dysregulation leads to bone diseases like osteoporosis due to impaired bone resorption. DOCK5 interacts with the DOCK–ELMO complex to mediate Rac1 activation. In cancer, DOCK5 enhances tumor cell motility and metastasis. Mouse models lacking DOCK5 exhibit reduced osteoclast activity and defects in immune cell migration.

Características del producto

category

ELISA Kits


immunogen target

Dedicator of cytokinesis protein 5 (DOCK5)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

DOCK5


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

DOCK5


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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