Human Dedicator of cytokinesis protein 5 (DOCK5) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DOCK5
proveedor
Abbexareference
abx510795Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Dedicator of cytokinesis protein 5 (DOCK5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Dedicator of cytokinesis protein 5 (DOCK5) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
DOCK5, structurally similar to DOCK1, acts as a GEF for Rac1 and Cdc42, regulating actin polymerization during cell migration and bone resorption. It is essential for osteoclast function, promoting cytoskeletal organization and podosome formation. DOCK5 is expressed in skeletal and immune tissues, playing roles in osteoclast-mediated bone remodeling and macrophage migration. Dysregulation leads to bone diseases like osteoporosis due to impaired bone resorption. DOCK5 interacts with the DOCK–ELMO complex to mediate Rac1 activation. In cancer, DOCK5 enhances tumor cell motility and metastasis. Mouse models lacking DOCK5 exhibit reduced osteoclast activity and defects in immune cell migration.
Características del producto
category
ELISA Kits
immunogen target
Dedicator of cytokinesis protein 5 (DOCK5)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
DOCK5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DOCK5
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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