Dedicator of Cytokinesis Protein 5 (DOCK5) Antibody
357.5€ (100 µg)
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name
Dedicator of Cytokinesis Protein 5 (DOCK5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122686
tested applications
ELISA, IHC
Description
Rabbit Polyclonal against the DOCK5 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dedicator of Cytokinesis Protein 5 (DOCK5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H7D0 |
| Gene ID | 80005 |
| NCBI Accession | BC011877 |
| OMIM | 616904 |
| Alias | DOCK5 |
| Background | Antibody anti-DOCK5 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
DOCK5, structurally similar to DOCK1, acts as a GEF for Rac1 and Cdc42, regulating actin polymerization during cell migration and bone resorption. It is essential for osteoclast function, promoting cytoskeletal organization and podosome formation. DOCK5 is expressed in skeletal and immune tissues, playing roles in osteoclast-mediated bone remodeling and macrophage migration. Dysregulation leads to bone diseases like osteoporosis due to impaired bone resorption. DOCK5 interacts with the DOCK–ELMO complex to mediate Rac1 activation. In cancer, DOCK5 enhances tumor cell motility and metastasis. Mouse models lacking DOCK5 exhibit reduced osteoclast activity and defects in immune cell migration.
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