Dedicator of Cytokinesis Protein 5 (DOCK5) Antibody
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935106861
info@markelab.com
Precio
357.5€ (100 µg)
Antibody anti-DOCK5
proveedor
Abbexareference
abx122686Tested Applications
ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Rabbit Polyclonal against the DOCK5 protein.
Background
DOCK5, structurally similar to DOCK1, acts as a GEF for Rac1 and Cdc42, regulating actin polymerization during cell migration and bone resorption. It is essential for osteoclast function, promoting cytoskeletal organization and podosome formation. DOCK5 is expressed in skeletal and immune tissues, playing roles in osteoclast-mediated bone remodeling and macrophage migration. Dysregulation leads to bone diseases like osteoporosis due to impaired bone resorption. DOCK5 interacts with the DOCK–ELMO complex to mediate Rac1 activation. In cancer, DOCK5 enhances tumor cell motility and metastasis. Mouse models lacking DOCK5 exhibit reduced osteoclast activity and defects in immune cell migration.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Dedicator of Cytokinesis Protein 5 (DOCK5)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Lyophilized
tested applications
ELISA, IHC
purification
Purified by antigen affinity column chromatography.
recommended dilution
ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
size 1
100 µg
size 2
1 mg
storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
or code
DOCK5
dry ice
No
availability
Shipped within 7-15 working days.
alias
DOCK5
uniprot id
NCBI accession
BC011877
note
Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -
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