Human Dedicator Of Cytokinesis Protein 1 (DOCK1) ELISA Kit

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator Of Cytokinesis Protein 1 (DOCK1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DOCK1

proveedor

Abbexa

reference

abx259546

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Dedicator Of Cytokinesis Protein 1 (DOCK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOCK180 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.

Características del producto

category

ELISA Kits


immunogen target

Dedicator Of Cytokinesis Protein 1 (DOCK1)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

DOCK1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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