Human Dedicator Of Cytokinesis 1 (DOCK1) Protein

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator Of Cytokinesis 1 (DOCK1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein DOCK1

proveedor

Abbexa

reference

abx066282

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Dedicator Of Cytokinesis 1 (DOCK1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Dedicator Of Cytokinesis 1 (DOCK1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr1200-Gln1435 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DOCK1


dry ice

No


availability

Shipped within 5-7 working days.


alias

DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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proveedor

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reference

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reactivity

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status

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clonality

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