Loading...
Human Dedicator Of Cytokinesis 1 (DOCK1) Protein
Pida mas información
935106861
info@markelab.com
Precio
212.5€ (10 µg)
Protein DOCK1
proveedor
Abbexareference
abx066282Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Dedicator Of Cytokinesis 1 (DOCK1) is a recombinant Human protein produced in E. coli using Prokaryotic expression.
Background
DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Dedicator Of Cytokinesis 1 (DOCK1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
DOCK1
dry ice
No
availability
Shipped within 5-7 working days.
alias
DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
anti- DOCK180 antibody
proveedor
FineTestreference
FNab02492Tested Applications
ELISA, WB, IHC, IF, IPreactivity
humanstatus
RUOclonality
polyclonalPrecio a consultar
Ver másanti- DOCK180-Specific antibody
proveedor
FineTestreference
FNab02493Tested Applications
ELISA, WB, IFreactivity
human,mouse,ratstatus
RUOclonality
polyclonalPrecio a consultar
Ver másDedicator of Cytokinesis 1 (DOCK1) Antibody
proveedor
Abbexareference
abx014419Tested Applications
ELISA, WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalRabbit polyclonal antibody against DOCK1 protein. Immunogen region is C-terminal.
43.75€ (10 µg)
Ver más