Human Dedicator Of Cytokinesis 3 (DOCK3) Protein
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935106861
info@markelab.com
Precio
1872€ (1 mg)
Protein DOCK3
proveedor
Abbexareference
abx653130Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Dedicator Of Cytokinesis 3 (DOCK3) Protein is a Recombinant Human protein expressed in E. coli.
Background
DOCK3, or MOCA, is a neuron-specific GEF for Rac1 that regulates neurite outgrowth, axonal growth, and synaptic plasticity in the CNS. It mediates actin rearrangement, promoting axonal guidance and dendritic remodeling. Highly expressed in neurons, DOCK3 maintains synapse connectivity and supports neuroprotection. Dysregulation contributes to neurodegenerative diseases like Alzheimer’s, where it influences tau phosphorylation and cell survival pathways such as ERK/Akt activation. DOCK3 deficiency causes motor and cognitive impairments in mouse models, highlighting its role in neuronal development, CNS recovery, and axonal regeneration.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Dedicator Of Cytokinesis 3 (DOCK3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
DOCK3
dry ice
No
availability
Shipped within 1-2 months.
alias
DOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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