Human Dedicator Of Cytokinesis 3 (DOCK3) Protein

1872€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Dedicator Of Cytokinesis 3 (DOCK3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653130
tested applications
WB, SDS-PAGE
Description
Human Dedicator Of Cytokinesis 3 (DOCK3) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Dedicator Of Cytokinesis 3 (DOCK3) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 1 mg |
Size 2 | 5 mg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 1-2 months. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | DOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA |
Background | Protein DOCK3 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
DOCK3, or MOCA, is a neuron-specific GEF for Rac1 that regulates neurite outgrowth, axonal growth, and synaptic plasticity in the CNS. It mediates actin rearrangement, promoting axonal guidance and dendritic remodeling. Highly expressed in neurons, DOCK3 maintains synapse connectivity and supports neuroprotection. Dysregulation contributes to neurodegenerative diseases like Alzheimer’s, where it influences tau phosphorylation and cell survival pathways such as ERK/Akt activation. DOCK3 deficiency causes motor and cognitive impairments in mouse models, highlighting its role in neuronal development, CNS recovery, and axonal regeneration.
Related Products

anti- DOCK3; MOCA antibody
Ver Producto
Recombinant Human DOCK3
Ver Producto
Dedicator of Cytokinesis 3 (DOCK3) Antibody
Dedicator Of Cytokinesis 3 Antibody is a Rabbit Polyclonal antibody against Dedicator Of Cytokinesis 3.
Ver Producto