DOCK3 antibody
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935106861
info@markelab.com
name
DOCK3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02494
tested applications
ELISA, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dedicator of cytokinesis 3 (DOCK3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 233 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IZD9 |
| Alias | DOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA |
| Background | Antibody anti-DOCK3 |
| Status | RUO |
| Note | Mol. Weight 233 kDa |
DOCK3, or MOCA, is a neuron-specific GEF for Rac1 that regulates neurite outgrowth, axonal growth, and synaptic plasticity in the CNS. It mediates actin rearrangement, promoting axonal guidance and dendritic remodeling. Highly expressed in neurons, DOCK3 maintains synapse connectivity and supports neuroprotection. Dysregulation contributes to neurodegenerative diseases like Alzheimer’s, where it influences tau phosphorylation and cell survival pathways such as ERK/Akt activation. DOCK3 deficiency causes motor and cognitive impairments in mouse models, highlighting its role in neuronal development, CNS recovery, and axonal regeneration.
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