Human DDB1- and CUL4-associated factor 8 (DCAF8) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DCAF8
proveedor
Abbexareference
abx509779Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human DDB1- and CUL4-associated factor 8 (DCAF8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DDB1- and CUL4-associated factor 8 (DCAF8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
DDB1 and CUL4 associated factor 8 (DCAF8) acts as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex and is involved in regulating protein degradation processes that maintain cellular homeostasis. DCAF8 is characterized by its WD40 repeat domains, which allow it to specifically bind to target substrates and facilitate their ubiquitination. Although its specific substrates are not yet fully defined, DCAF8 is thought to play a role in regulating the cell cycle and DNA damage responses, contributing to genomic stability. Its expression is ubiquitous, with enhanced activity in tissues requiring tight regulation of proteostasis. Dysfunction of DCAF8 has been linked to impaired ubiquitin-mediated protein degradation, which can lead to cellular stress and contribute to disease. Ongoing studies aim to clarify its role in transcriptional regulation and signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
DDB1- and CUL4-associated factor 8 (DCAF8)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GAN2,H326,WDR42A,WD repeat-containing protein 42A
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DCAF8
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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