DDB1 And CUL4 Associated Factor 8 (DCAF8) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
DDB1 And CUL4 Associated Factor 8 (DCAF8) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx313426
tested applications
ELISA
Description
DCAF8 Antibody (Biotin) is a Rabbit Polyclonal against DCAF8 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DDB1 And CUL4 Associated Factor 8 (DCAF8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5TAQ9 |
| Gene ID | 50717 |
| NCBI Accession | NP_056541.2, NM_015726.3 |
| OMIM | 610100 |
| Alias | GAN2,H326,WDR42A,WD repeat-containing protein 42A |
| Background | Antibody anti-DCAF8 |
| Status | RUO |
Descripción
DDB1 and CUL4 associated factor 8 (DCAF8) acts as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex and is involved in regulating protein degradation processes that maintain cellular homeostasis. DCAF8 is characterized by its WD40 repeat domains, which allow it to specifically bind to target substrates and facilitate their ubiquitination. Although its specific substrates are not yet fully defined, DCAF8 is thought to play a role in regulating the cell cycle and DNA damage responses, contributing to genomic stability. Its expression is ubiquitous, with enhanced activity in tissues requiring tight regulation of proteostasis. Dysfunction of DCAF8 has been linked to impaired ubiquitin-mediated protein degradation, which can lead to cellular stress and contribute to disease. Ongoing studies aim to clarify its role in transcriptional regulation and signaling pathways.
Related Products
DDB1 And CUL4 Associated Factor 8 (DCAF8) Antibody (HRP)
DCAF8 Antibody (HRP) is a Rabbit Polyclonal against DCAF8 conjugated to HRP.
Ver Producto
DDB1 And CUL4 Associated Factor 8 (DCAF8) Antibody (FITC)
DCAF8 Antibody (FITC) is a Rabbit Polyclonal against DCAF8 conjugated to FITC.
Ver ProductoDDB1 And CUL4 Associated Factor 8 (DCAF8) Antibody (Biotin)
DCAF8 Antibody (Biotin) is a Rabbit Polyclonal against DCAF8 conjugated to Biotin.
Ver Producto