Human DDB1- and CUL4-associated factor 15 (DCAF15) ELISA Kit

Este producto es parte de DCAF - DDB1 and CUL4 associated factor
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715€ (96 tests)

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935106861
info@markelab.com
name
Human DDB1- and CUL4-associated factor 15 (DCAF15) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx509764
tested applications
ELISA

Description

Human DDB1- and CUL4-associated factor 15 (DCAF15) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DDB1- and CUL4-associated factor 15 (DCAF15) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
DDB1- and CUL4-associated factor 15 (DCAF15)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q66K64
Alias
C19orf72
Background
Elisa kits for DCAF15
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

DDB1 and CUL4 associated factor 15 (DCAF15) serves as a key substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex, involved in protein degradation and cellular regulation. DCAF15 is notable for its unique ability to interact with specific substrates, including RBM39, a splicing factor targeted for ubiquitin-mediated degradation by the sulfonamide family of drugs. This interaction has been extensively studied in the context of targeted protein degradation, particularly in cancer therapy. DCAF15 contains WD40 repeats that facilitate the recognition of proteins destined for ubiquitination, mediating their recruitment to the E3 ligase complex. It plays a role in regulating RNA splicing and transcription, as well as in maintaining cellular proteostasis. The expression pattern of DCAF15 across tissues and its involvement in essential cellular processes underscore its significance in both normal physiology and disease states, especially as a therapeutic target in cancers reliant on RBM39.
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