Human DDB1 And CUL4 Associated Factor 12 (DCAF12) ELISA Kit
715€ (96 tests)
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name
Human DDB1 And CUL4 Associated Factor 12 (DCAF12) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx384293
tested applications
ELISA
Description
Human DDB1 And CUL4 Associated Factor 12 (DCAF12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human WDR40A concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DDB1 And CUL4 Associated Factor 12 (DCAF12) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5T6F0 |
| Gene ID | 25853 |
| Alias | CT102,TCC52,WDR40A,KIAA1892,WD repeat-containing protein 40A,Testis cancer centrosome-related protein,Centrosome-related protein TCC52 |
| Background | Elisa kits for DCAF12 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DDB1 and CUL4 associated factor 12 (DCAF12) acts as a substrate receptor within the CUL4-DDB1 E3 ubiquitin ligase complex, playing a vital role in ubiquitin-mediated protein degradation. This process ensures the stability of key proteins required for various cellular functions. DCAF12 contains WD40 repeats that facilitate specific protein-protein interactions, allowing it to recognize substrates with a C-terminal diglutamate (Glu-Glu) motif and target them for ubiquitination and subsequent proteasomal degradation. One prominent example is MOV10, an RNA helicase involved in spermatogenesis and T-cell activation, whose stability is regulated by DCAF12 through recognition of a specific Glu-Leu degron. Furthermore, DCAF12 is involved in modulating apoptosis by interacting with inhibitor of apoptosis proteins (IAPs) and regulates NF-κB signaling, highlighting its importance in cell survival pathways. Its expression is ubiquitous, with particularly high levels in early spermatids, underscoring its role in male reproduction. These characteristics highlight its importance in maintaining cellular homeostasis and in specialized functions related to reproductive biology.
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