Human DCC(Netrin receptor DCC) ELISA Kit
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935106861
info@markelab.com
Precio
Precio a consultar
Elisa Kits DCC
proveedor
FineTestreference
EH7828Tested Applications
reactivity
humanstatus
RUOclonality
Background
The DCC (Deleted in Colorectal Carcinoma) receptor is a key transmembrane protein that functions as a receptor for netrin-1, a secreted guidance cue that directs axon growth and neuronal migration during embryonic development. DCC is essential for axon guidance, mediating attraction of neuronal growth cones toward sources of netrin-1 in the developing nervous system. Structurally, DCC contains immunoglobulin-like and fibronectin-type III domains in its extracellular region, enabling interaction with netrin-1, and intracellular domains that recruit signaling proteins, such as the Src family kinases, to transduce guidance signals. Beyond its role in neural development, DCC is also implicated in maintaining tissue homeostasis, acting as a dependence receptor to induce apoptosis in the absence of netrin-1. Mutations or loss of DCC expression have been associated with colorectal cancer and other malignancies, highlighting its role as a tumor suppressor. DCC is highly expressed in the developing central nervous system, particularly in commissural neurons, and its functions in axon guidance are critical for establishing proper neural circuitry.
Características del producto
category
ELISA Kits
reactivity
human
test range
0.156-10ng/ml
assay type
Sandwich ELISA, Double Antibody
assay data
Quantitative
detection method
Colorimetric
sample type
Busacar en las instrucciones
size 1
96T
alias
CRC18,CRCR1,MRMV1,HGPPS2,IGDCC1,NTN1R1,Tumor suppressor protein DCC,Immunoglobulin superfamily DCC subclass member 1,Colorectal cancer suppressor
storage
2-8 °C for 6 months
or code
DCC
uniprot id
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