Human Cysteinyl Leukotriene Receptor 2 (CYSLTR2) CLIA Kit
845€ (96 tests)
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name
Human Cysteinyl Leukotriene Receptor 2 (CYSLTR2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493151
tested applications
CLIA
Description
Cysteinyl Leukotriene Receptor 2 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Cysteinyl Leukotriene Receptor 2 (CYSLTR2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.122 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CYSLTR2,CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21,LTC4 |
| Background | CLIA Kits CYSLTR2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CYSLTR2 is a G protein-coupled receptor that binds cysteinyl leukotrienes, particularly LTC4 and LTD4, with a lower affinity for LTE4. CYSLTR2 is expressed in smooth muscle cells, endothelial cells, and immune cells, where it mediates inflammatory responses similar to CYSLTR1. CYSLTR2 activation leads to smooth muscle contraction, increased vascular permeability, and cytokine production through the phospholipase C (PLC)/calcium signaling pathway. While CYSLTR1 is more involved in acute bronchoconstriction, CYSLTR2 appears to play a complementary role in chronic inflammation, fibrosis, and tissue remodeling. Dysregulation of CYSLTR2 contributes to diseases such as asthma, pulmonary fibrosis, and cardiovascular conditions, where cysteinyl leukotriene signaling promotes tissue damage and chronic inflammation. Emerging evidence suggests CYSLTR2's involvement in cancer progression, particularly in promoting tumor-associated inflammation and angiogenesis. Targeting CYSLTR2, in combination with CYSLTR1 antagonists, is being explored to improve therapeutic outcomes in severe asthma, fibrosis, and inflammatory diseases.
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