Human Cysteinyl Leukotriene Receptor 1 (CYSLTR1) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for CYSLTR1
proveedor
Abbexareference
abx151230Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Cysteinyl Leukotriene Receptor 1 (CYSLTR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Cysteinyl Leukotriene Receptor 1 concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Background
CYSLTR1 is a G protein-coupled receptor (GPCR) that binds cysteinyl leukotrienes (CysLTs), including leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4). It is highly expressed in smooth muscle cells, mast cells, eosinophils, and airway epithelial cells. CYSLTR1 signaling plays a central role in allergic and inflammatory responses, particularly in asthma and allergic rhinitis, where it mediates bronchoconstriction, vascular permeability, and mucus production. Activation of CYSLTR1 triggers the phospholipase C (PLC) pathway, leading to calcium mobilization and smooth muscle contraction. CYSLTR1 is also implicated in chronic inflammatory diseases such as atopic dermatitis and cardiovascular disorders. Its overactivation exacerbates tissue damage, airway hyperresponsiveness, and immune cell recruitment. Leukotriene receptor antagonists (LTRAs), such as montelukast and zafirlukast, target CYSLTR1 and are used clinically to manage asthma and allergic inflammation by blocking cysteinyl leukotriene signaling. CYSLTR1 remains a critical therapeutic target for allergic and inflammatory diseases.
Características del producto
category
ELISA Kits
immunogen target
Cysteinyl Leukotriene Receptor 1 (CYSLTR1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.09 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
CYSLTR1,CYSLT1,CYSLT1R,CYSLTR,HMTMF81,HG55,LTD4,leukotriene D4 receptor
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
CYSLTR1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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