Human Corticotropin Releasing Hormone Receptor 1 (CRHR1) ELISA Kit

Product specifications

ELISA Kits

Corticotropin Releasing Hormone Receptor 1 (CRHR1)

Human

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.06 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

CRHR1,CRFR1,CRF-R,CRHR,CRH-R1,CRF-R1alpha,CRF 1 receptor,CRF-RA,CRF1,CRF-R1,CRFR-1,CRHR1L

Elisa kits for CRHR1

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CRHR1 is a G protein-coupled receptor (GPCR) that binds corticotropin-releasing hormone (CRH) and related peptides like urocortin 1, playing a central role in the hypothalamic-pituitary-adrenal (HPA) axis. CRHR1 is highly expressed in the brain, particularly in the hypothalamus, pituitary gland, and cerebral cortex, where it regulates stress responses by stimulating the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. Activation of CRHR1 triggers signaling pathways such as cAMP/PKA, MAPK, and calcium mobilization, leading to cellular responses that modulate stress, behavior, and emotional regulation. CRHR1 is implicated in stress-related disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD), where dysregulated CRH signaling disrupts HPA axis activity and leads to chronic stress responses. CRHR1 also plays roles in energy metabolism, immune regulation, and inflammation, with emerging evidence linking it to conditions like obesity and inflammatory diseases. In cancer, CRHR1 overexpression has been observed in melanoma and other tumors, where CRH signaling promotes cell proliferation and survival. Pharmacological inhibitors of CRHR1, such as antagonists, are being explored as potential treatments for anxiety disorders, depression, and stress-induced metabolic dysfunctions, highlighting its importance in neuroendocrine regulation and disease.

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This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene.

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