Human Contactin 2 (CNTN2) Protein (Active)
1079€ (100 µg)
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name
Human Contactin 2 (CNTN2) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691806
tested applications
SDS-PAGE
Description
Human Contactin 2 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CNTN2 (NP_005067.1) precursor (Met 1-Asn 1012) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Contactin 2 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 109 kDa Sequence Fragment: Met1-Asn1012 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_005067.1 |
| Alias | AXT,TAX,TAX1,EPEO5,FAME5,TAG-1,Transient axonal glycoprotein 1,Axonin-1,Axonal glycoprotein TAG-1,Contactin-2 |
| Background | Protein CNTN2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Contactin 2 (CNTN2), also known as TAG-1 (Transient Axonal Glycoprotein 1), is another GPI-anchored neural adhesion molecule involved in axonal guidance, synaptic development, and neuron-glia interactions. CNTN2 is predominantly expressed during development in the central and peripheral nervous systems, where it plays a critical role in axon fasciculation, neurite outgrowth, and myelination. It interacts with receptors such as L1CAM, Caspr2, and other contactins to promote the formation of functional neural circuits. CNTN2 is also implicated in the organization of nodes of Ranvier, where it stabilizes interactions between axons and myelinating glial cells. Genetic studies have linked CNTN2 mutations to neurodevelopmental and neuropsychiatric disorders, including autism and epilepsy, where its dysregulation disrupts neural connectivity and excitability. It has also been studied in the context of autoimmune diseases like multiple sclerosis, where anti-CNTN2 antibodies contribute to neuroinflammation and demyelination. Structurally, CNTN2 shares immunoglobulin-like and fibronectin type III domains with other contactins, allowing it to mediate dynamic and specific cell-cell interactions in the nervous system.
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