Human Complement Receptor 2 / CD21 (CR2) Protein

Este producto es parte de CR2 - complement C3d receptor 2
Human Complement Receptor 2 / CD21 (CR2) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein CR2

proveedor

Abbexa

reference

abx066088

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Complement Receptor 2 (CR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

CR2, also known as complement receptor type 2 (CR2) or CD21, is a crucial protein involved in the immune response, particularly in the regulation and activation of B cells and the complement system. It serves as a receptor for fragments of complement component C3, specifically C3d, C3dg, and iC3b, which are breakdown products of C3b, an integral part of the complement system. By binding these complement fragments, CR2 plays a key role in amplifying the immune response and facilitating interactions between the innate and adaptive arms of the immune system. CR2 is predominantly expressed on the surface of B lymphocytes, follicular dendritic cells, and some epithelial cells. Its most well-known function is to enhance B-cell activation by linking the complement system to the B-cell receptor (BCR) signaling pathway. This enhances B-cell sensitivity to antigens, especially during the formation of immunological memory.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Complement Receptor 2 / CD21 (CR2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 55.1 kDa Observed MW (SDS-PAGE): 55 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys729-Ser957 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CR2


dry ice

No


availability

Shipped within 5-7 working days.


alias

CR,C3DR,CD21,CVID7,SLEB9,Complement receptor type 2,Complement C3d receptor,Epstein-Barr virus receptor,EBV receptor


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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