Human Colony Stimulating Factor 2 Receptor Beta (CSF2Rb) Protein (Active)
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Description
Human CD131 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Trp 443) of human CSF2RB (NP_000386.1) expressed, fused with a polyhistidine-tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD131 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 50 kDa Sequence Fragment: Met1-Trp443 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_000386.1 |
| Alias | Cytokine receptor common subunit beta,CD131,IL3RB,IL5RB,SMDP5,CDw131,betaGMR,GM-CSF/IL-3/IL-5 receptor common beta subunit |
| Background | Protein CSF2RB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The Colony Stimulating Factor 2 Receptor Subunit Beta (CSF2RB), also known as common beta chain (βc), is an integral part of the receptor complex for several cytokines, notably granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). These cytokines play essential roles in hematopoiesis, the immune system, and inflammatory processes by driving the proliferation, differentiation, and activation of various hematopoietic cells. CSF2RB is thus crucial for normal immune function and has also been implicated in inflammatory responses, tissue repair, and pathological conditions such as chronic inflammation and certain cancers. Unlike its alpha counterparts (CSF2RA, IL3RA, and IL5RA), which are cytokine-specific, CSF2RB serves as a shared receptor subunit in these cytokine receptor complexes. This shared receptor structure allows it to transmit signals from multiple cytokines, although it does not bind cytokines directly. Instead, CSF2RB’s main function is to initiate downstream signaling cascades once the cytokine and alpha subunit have bound, forming a functional receptor complex. This receptor complex predominantly activates the JAK/STAT and MAPK signaling pathways, with substantial impact on immune responses, hematopoiesis, and cellular responses to stress.
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