CSF2RB (pY766) Antibody
292.5€ (80 µl)
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name
CSF2RB (pY766) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031871
tested applications
ELISA, DB
Description
CSF2RB (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CSF2RB (pY766) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr766 |
| Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, DB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32927 |
| Alias | Cytokine receptor common subunit beta,CD131,IL3RB,IL5RB,SMDP5,CDw131,betaGMR,GM-CSF/IL-3/IL-5 receptor common beta subunit |
| Background | Antibody anti-CSF2RB |
| Status | RUO |
Descripción
The Colony Stimulating Factor 2 Receptor Subunit Beta (CSF2RB), also known as common beta chain (βc), is an integral part of the receptor complex for several cytokines, notably granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). These cytokines play essential roles in hematopoiesis, the immune system, and inflammatory processes by driving the proliferation, differentiation, and activation of various hematopoietic cells. CSF2RB is thus crucial for normal immune function and has also been implicated in inflammatory responses, tissue repair, and pathological conditions such as chronic inflammation and certain cancers. Unlike its alpha counterparts (CSF2RA, IL3RA, and IL5RA), which are cytokine-specific, CSF2RB serves as a shared receptor subunit in these cytokine receptor complexes. This shared receptor structure allows it to transmit signals from multiple cytokines, although it does not bind cytokines directly. Instead, CSF2RB’s main function is to initiate downstream signaling cascades once the cytokine and alpha subunit have bound, forming a functional receptor complex. This receptor complex predominantly activates the JAK/STAT and MAPK signaling pathways, with substantial impact on immune responses, hematopoiesis, and cellular responses to stress.
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CSF2RB (pY766) Antibody
CSF2RB (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.
Ver Producto